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Anyone who has ever been sexually active (that is, engaged in skin-to-skin sexual conduct, including vaginal, anal, or oral sex) can get HPV.HPV is easily passed between partners through sexual contact.High-risk HPV types cause approximately 5% of all cancers worldwide (11).In the United States, high-risk HPV types cause approximately 3% of all cancer cases among women and 2% of all cancer cases among men (12).

The Food and Drug Administration (FDA) has approved three vaccines to prevent HPV infection: Gardasil®, Gardasil® 9, and Cervarix®.

Some HPV infections, however, can persist for many years.

Persistent infections with high-risk HPV types can lead to cell changes that, if untreated, may progress to cancer.

These vaccines provide strong protection against new HPV infections, but they are not effective at treating established HPV infections or disease caused by HPV (15, 16).

Correct and consistent condom use is associated with reduced HPV transmission between sexual partners, but less frequent condom use is not (8).

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Cervarix is approved for use in females ages 9 through 25 for the prevention of HPV-caused cervical cancer.

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